SELECT trial information

The double-blinded SELECT cardiovascular outcomes trial compared subcutaneous once-weekly semaglutide 2.4 mg with placebo as an adjunct to standard of care for prevention of major adverse cardiovascular (MACE) events over a period of up to 5 years. Read more about its background, methodology, results, and more.

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SELECT Trial Video

Obesity as a risk factor for ASCVD Video

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Impact of Weight Reduction on CVD

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SELECT Trial Design and Rationale

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SELECT Inclusion Exclusion Criteria and Dosing

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SELECT Baseline Characteristics

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SELECT Primary Efficacy & Safety

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SELECT Trial PDF

SELECT CVOT overview

Overview of SELECT CVOT trial, design, efficacy and safety results.

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Trial Objectives

Trial Objectives for the SELECT trial

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Baseline Characteristics

Baseline Characteristics for the SELECT trial

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Semaglutide s.c. 2.4 mg OW is not indicated for MACE risk reduction. Safety and efficacy are not established for this use under investigation. Semaglutide s.c. 2.4 mg OW is FDA-approved for chronic weight management in adults with obesity (BMI > 30), or overweight (excess weight) (BMI > 27) who also have weight-related medical problems, used with a reduced-calorie meal plan and increased physical activity. Semaglutide s.c. 2.4 mg OW is also indicated for use in patients aged 12 years and older with an initial BMI at or above the 95th percentile for age and sex. Please see the full prescribing information for Semaglutide s.c. 2.4 mg OW here. Novo Nordisk does not recommend or suggest use of its medicines in a manner inconsistent with FDA-approved labeling.

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Trial Rationale

Trial Rationale for the SELECT trial

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Additional Information

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